Chk-ing in and Chk-ing out: Kinase Compartmentalization Comes to Checkpoint Control
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چکیده
منابع مشابه
Chk-ing in and Chk-ing out: kinase compartmentalization comes to checkpoint control.
Checkpoints are the sentinels of cell-cycle progression. In this issue of Molecular Cell, Yaffe and colleagues (Reinhardt et al., 2010) show that spatial and temporal resolution of Chk1 and MK2, checkpoint kinases with identical substrate specificity, are necessary to signal different aspects of DNA damage signaling.
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2010
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2010.09.020